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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FECH All Species: 39.7
Human Site: S195 Identified Species: 67.18
UniProt: P22830 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22830 NP_000131.2 423 47862 S195 F T Q Y P Q Y S C S T T G S S
Chimpanzee Pan troglodytes Q3YA36 423 47946 S195 F T Q Y P Q Y S C S T T G S S
Rhesus Macaque Macaca mulatta XP_001085580 422 47841 S194 F T Q Y P Q Y S C S T T G S S
Dog Lupus familis XP_852936 400 45170 A182 T T G S S L N A I Y R Y Y N K
Cat Felis silvestris
Mouse Mus musculus P22315 420 47112 S192 F T Q Y P Q Y S C S T T G S S
Rat Rattus norvegicus NP_001101904 422 47533 S194 F T Q Y P Q Y S C S T T G S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510557 430 49042 S202 F T Q Y P Q Y S C S T T G S S
Chicken Gallus gallus O42479 402 45411 S174 F T Q Y P Q Y S C S T T G S S
Frog Xenopus laevis O57478 411 46021 S182 F T Q Y P Q Y S C S T T G S S
Zebra Danio Brachydanio rerio NP_571706 409 46017 S181 F T Q Y P Q Y S C S T T G S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V9S8 384 43579 N174 F T H Y R S N N L P S D I K W
Honey Bee Apis mellifera XP_393413 397 45521 E178 T S G S S F I E I Y K Y Y K N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04921 512 56600 S229 L P L Y P Q F S I S T S G S S
Baker's Yeast Sacchar. cerevisiae P16622 393 44578 E177 T T G S S I N E L W R Q I K A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 96.9 86 N.A. 88.1 88.8 N.A. 82.7 79.6 78.4 71.8 N.A. 49.1 48.2 N.A. N.A.
Protein Similarity: 100 99 96.9 89.5 N.A. 92.6 93.1 N.A. 89.3 85.1 85.3 81.8 N.A. 64.7 66.4 N.A. N.A.
P-Site Identity: 100 100 100 6.6 N.A. 100 100 N.A. 100 100 100 100 N.A. 20 0 N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 100 N.A. 100 100 100 100 N.A. 33.3 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 32.2 45.1 N.A.
Protein Similarity: N.A. N.A. N.A. 47.2 62.6 N.A.
P-Site Identity: N.A. N.A. N.A. 60 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 65 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 % E
% Phe: 72 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 22 0 0 0 0 0 0 0 0 0 72 0 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 8 0 22 0 0 0 15 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 8 0 0 22 8 % K
% Leu: 8 0 8 0 0 8 0 0 15 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 22 8 0 0 0 0 0 8 8 % N
% Pro: 0 8 0 0 72 0 0 0 0 8 0 0 0 0 0 % P
% Gln: 0 0 65 0 0 72 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 0 0 0 8 0 0 0 0 0 15 0 0 0 0 % R
% Ser: 0 8 0 22 22 8 0 72 0 72 8 8 0 72 72 % S
% Thr: 22 86 0 0 0 0 0 0 0 0 72 65 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % W
% Tyr: 0 0 0 79 0 0 65 0 0 15 0 15 15 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _